CADMIUM INDUCED OXIDATIVE STRESS IN TESTIS OF MALE ALBINO RATS | ||||
| Journal of the Egyptian Veterinary Medical Association | ||||
| Volume 76, Issue 2, July 2016, Page 249-261 PDF (720.61 K) | ||||
| Document Type: Original Research Articles | ||||
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| Abstract | ||||
| Cadmium is ubiquitous environmental and occupational pollutant. It is mainly used in the manufacture of nickel- cadmium batteries, pigments and plastic stabilizers. This study was designed to investigate the ability of Cd to induce oxidative stress in the testes of male albino rats with consequent male reproductive hormones production. Ninety adult male albino rats were used in this study. They were divided into 3 equal groups, group 1: control; group 2: received Cd at 30 mg/L in drinking water for 8 weeks and group 3: received Cd at 60 mg/L in drinking water for 8 weeks. Rats were sacrificed at the end of the 4th, 6th and 8th weeks for collection of blood and testicular samples. The results revealed that Cd induced oxidative stress in the testes of male albino rats as evidenced by marked reduction in antioxidant enzymatic activities such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and reduced glutathione (GSH) level. Exposure to Cd also resulted in lipid peroxidation as indicated by significant increase in testicular MDA level. Testosterone, LH and FSH levels were also significantly decreased in blood as a result of exposure to Cd. Marked histopathological changes ranging from detachment and sloughing to vacuolization of the seminiferous tubules appeared in the testes of rats exposed to Cd. | ||||
| Keywords | ||||
| Cadmium; oxidative stress; antioxidant enzymes; testosterone; rat; testes | ||||
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