Alterations in biochemical parameters and hepatic ultrasonography with reference to oxidant injury in ketotic dairy cows | ||||
| Benha Veterinary Medical Journal | ||||
| Article 33, Volume 31, Issue 2, December 2016, Page 231-240 PDF (383.51 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bvmj.2016.31304 | ||||
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| Authors | ||||
| Ghanem M. M.1; Mahmoud M. E.2; Abd El-Raof Y. M.1; El-Attar H. M.1 | ||||
| 1Animal Medicine Department, Faculty of Vet. Medicine, Benha University | ||||
| 2Animal Medicine Dept., Faculty of Veterinary Medicine, Aswan University | ||||
| Abstract | ||||
| This study aimed to evaluate the clinical, biochemical and hepatic ultrasonographic changes in ketotic dairy cows. For that purpose, we examined 42 lactating Holstein- Friesian cows with ages from 3- 10 years old during the post parturient period (up to 6 weeks postpartum). The cows were classified into control healthy (C=20), subclinical ketotic cows (SCK=17) and clinical ketotic cows (CK=5). Clinically, anorexia and reduction in milk yield were observed in CK cows. The ruminal movements showed a significant depression (P<0.05) in CK than SCK and control. The serum glucose, insulin and cortisol showed a highly significant decrease (P<0.001) in CK and SCK than control. The serum NEFA and BHBA showed a highly significant increase (P<0.001) in CK and SCK than control. Serum cholesterol and HDL levels showed a significant (P<0.01) decrease in SCK and CK cows than control. Serum triglycerides (TG) and very low density lipoprotein (VLDL) were significantly decreased (P<0.01) in CK than control. The serum activity of AST, ALT and GGT were significantly increased (P<0.05) in CK cows than control. Serum Ca and P levels were significantly decreased (P<0.05) in CK cows than SCK and control. Regarding the oxidative stress biomarkers, serum level of malondialdehyde (MDA) showed a highly significant (P<0.001) increase in CK cows than SCK and control whereas, serum superoxide dismutase (SOD) level was significantly decreased (P<0.05) in CK cows than control. Hepatic ultrasonography of ketotic cows revealed varying degrees of fatty infiltration (focal and diffuse fatty infiltration) appeared as increased hepatic echogenicity with a blurring of hepatic blood vessels. It is concluded that ketosis induced clinical, biochemical and ultrasonographical changes in lactating cows. Oxidant injury could be implicated in the pathogenesis of the disease | ||||
| Keywords | ||||
| Anti-oxidant; biochemical; ketosis; subclinical ketosis; Ultrasonography | ||||
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