Hepato-renal and splenic cytotoxic effects of American cockroach Periplaneta americana hemolymph in Solid Ehrlich carcinoma-bearing mice
osman, E., Tawfik, M., Ahmed Abdel Rahman, M., Hassan, M., Khalaf, A. (2024). Hepato-renal and splenic cytotoxic effects of American cockroach Periplaneta americana hemolymph in Solid Ehrlich carcinoma-bearing mice. EKB Journal Management System, 5(1), 16-25. doi: 10.21608/ajbas.2023.227694.1182
Esraa Gamal osman; Mohamed Mahmoud Tawfik; Mohamed Ahmed Abdel Rahman; Mohamed Kamel Hassan; Ahmed Khalaf. "Hepato-renal and splenic cytotoxic effects of American cockroach Periplaneta americana hemolymph in Solid Ehrlich carcinoma-bearing mice". EKB Journal Management System, 5, 1, 2024, 16-25. doi: 10.21608/ajbas.2023.227694.1182
osman, E., Tawfik, M., Ahmed Abdel Rahman, M., Hassan, M., Khalaf, A. (2024). 'Hepato-renal and splenic cytotoxic effects of American cockroach Periplaneta americana hemolymph in Solid Ehrlich carcinoma-bearing mice', EKB Journal Management System, 5(1), pp. 16-25. doi: 10.21608/ajbas.2023.227694.1182
osman, E., Tawfik, M., Ahmed Abdel Rahman, M., Hassan, M., Khalaf, A. Hepato-renal and splenic cytotoxic effects of American cockroach Periplaneta americana hemolymph in Solid Ehrlich carcinoma-bearing mice. EKB Journal Management System, 2024; 5(1): 16-25. doi: 10.21608/ajbas.2023.227694.1182

Hepato-renal and splenic cytotoxic effects of American cockroach Periplaneta americana hemolymph in Solid Ehrlich carcinoma-bearing mice

Alfarama Journal of Basic & Applied Sciences
Volume 5, Issue 1, January 2024, Page 16-25  XML PDF (935.01 K)
Document Type: Original Article
DOI: 10.21608/ajbas.2023.227694.1182
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Authors
Esraa Gamal osman email 1; Mohamed Mahmoud Tawfik2; Mohamed Ahmed Abdel Rahman3; Mohamed Kamel Hassan4; Ahmed Khalaf5
1biotechnology ,Zoology Department ,Faculty of Science, Port Said University
2Zoology Department, Faculty of Science, Port Said University, Port Said, Egypt
3Assistant Professor of Physiology Zoology Department Suez Canal University
4Faculty of Science, Port Said University, Appointed visiting professor at the Center for Genomics, Zewail City for Science and Technology
5Department of Zoology, Faculty of Science, Port Said University
Abstract
Cancer is one of the communal reasons -for death worldwide. Periplaneta americana (P. americana) hemolymph revealed a wide range of biological activities, including antibacterial, anticancer, antiviral, and antiinflammation. Using histopathological approaches, this study was conducted to evaluate the safety of P. americana hemolymph by investigating its toxicological effects on liver, kidney, and spleen tissues of Solid Ehrlich carcinoma cells bearing mice. The results showed remarkable inflammatory and necrotizing toxic effects of P. americana hemolymph on mice's liver with no remnant of liver tissues. It also induced tubular necrosis of renal tubular kidney tissue, and lymphoid hyperplasia with significant congested red pulp in spleen tissue after treatment for 14 days. These findings concluded that P. americana hemolymph has prominent hepato-renal and splenic cytotoxic effects of Solid Ehrlich carcinoma cells bearing mice. The histopathological data of P. americana hemolymph should be considered while using these materials in the discovery and development of anticancer agents.
Keywords
histology; Periplaneta americana; liver; kidney; hemolymph
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