Incidence, Risk Factors and Management of Central Venous Catheter Thrombosis in Neonatal Intensive Care Unit
AbdelAzim, M., abd-elhaie, O., Diab, A., Faheem, M. (2024). Incidence, Risk Factors and Management of Central Venous Catheter Thrombosis in Neonatal Intensive Care Unit. EKB Journal Management System, 9(2), 83-90. doi: 10.21608/bjas.2024.271547.1340
Mohammed Hatem AbdelAzim; Omima abd-elhaie; Aliaa Diab; Mohammed Faheem. "Incidence, Risk Factors and Management of Central Venous Catheter Thrombosis in Neonatal Intensive Care Unit". EKB Journal Management System, 9, 2, 2024, 83-90. doi: 10.21608/bjas.2024.271547.1340
AbdelAzim, M., abd-elhaie, O., Diab, A., Faheem, M. (2024). 'Incidence, Risk Factors and Management of Central Venous Catheter Thrombosis in Neonatal Intensive Care Unit', EKB Journal Management System, 9(2), pp. 83-90. doi: 10.21608/bjas.2024.271547.1340
AbdelAzim, M., abd-elhaie, O., Diab, A., Faheem, M. Incidence, Risk Factors and Management of Central Venous Catheter Thrombosis in Neonatal Intensive Care Unit. EKB Journal Management System, 2024; 9(2): 83-90. doi: 10.21608/bjas.2024.271547.1340

Incidence, Risk Factors and Management of Central Venous Catheter Thrombosis in Neonatal Intensive Care Unit

Benha Journal of Applied Sciences
Article 10, Volume 9, Issue 2, February 2024, Page 83-90  XML PDF (569.31 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2024.271547.1340
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Authors
Mohammed Hatem AbdelAzim email 1; Omima abd-elhaie2; Aliaa Diab3; Mohammed Faheem4
1Department of Pediatrics Faculty of Medicine - Benha University
2Prof.of pediatrics Faculty of Medicine- Benha University
3Lecturer of Pediatrics Faculty of Medicine - Benha University
4Lecturer of radiodiagnosis Faculty of Medicine-Benha University
Abstract
Background: Central venous catheter (CVC) thrombosis poses a significant challenge in neonatal intensive care units (NICUs). This study aimed to assess the incidence, identify risk factors, and explore management strategies for CVC thrombosis in neonates. Methods: The prospective study was conducted from September 2021 to February 2022 in Benha University Hospital and Benha Children Hospital. The study included 150 neonates with central venous lines. In-depth assessments, including medical history, examinations, laboratory investigations, and Doppler ultrasound, were employed. Results: Among the neonates, 12% experienced CVC thrombosis, with a mortality rate of 38%. Analysis revealed significant associations between thrombosis and factors such as gestational age (P < 0.001), weight (P < 0.001), and sepsis (P < 0.001). Laboratory findings indicated higher hematocrit levels (P < 0.0001) and elevated C-reactive protein (CRP) levels (P = 0.011) in neonates with positive thrombosis. Multivariate analysis identified duration of CVC > 8.52 as the most significant factor (OR = 109.948, P < 0.001), followed by infected CVC (OR = 40.203, P < 0.001) and hematocrit level > 54.32 (OR = 15.617, P = 0.002). ROC analysis demonstrated high predictive value for both hematocrit (AUC = 0.877, P < 0.001) and duration of CVC (AUC = 0.822, P < 0.001). Conclusions: Duration of CVC > 8.52, infected CVC, and elevated hematocrit levels were identified as significant risk factors for CVC thrombosis in neonates.
Keywords
CVC Thrombosis; Neonatal Intensive Care Unit; Risk Factors; Hematocrit; Mortality
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