IMPACT OF THE USE OF TACROLIMUS VERSUS CYCLOSPORINE ON CYTOMEGALOVIRUS COLITIS AND HEPATITIS IN POST RENAL TRANSPLANT PATIENTS | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 16, Volume 54, Issue 1, April 2024, Page 121-128 PDF (3.94 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2024.351364 | ||||
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| Authors | ||||
| NOURAN MOHAMED SAID; SAMEH MOHAMED GHALY; ESLAM SAFWAT MOHAMED; FADY MAGDY GAMIL; KARIM SAMY ABDALLA BAHNASY | ||||
| Department of Internal Medicine and Gastroenterology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt | ||||
| Abstract | ||||
| Cytomegalovirus (CMV) is a common viral infection after kidney transplantation (KT). Major risk factors for CMV infection include the overall immunosuppression intensity and the CMV serostatus. The study compared the use of Tacrolimus versus Cyclosporine on the incidence of cytomegalovirus (CMV) colitis and hepatitis in post renal transplant patients. This was a retrospective cohort study; in which 90 adult post renal transplant Egyptian patients were divided into 2 groups: G1: 45 patients on Tacrolimus, mycophenolate, steroids. G2:45 patients on Cyclosporine, mycophenolate, steroids. The results showed insignificant difference between both groups as to incidence of CMV colitis and hepatitis in positive CMV/PCR patients post renal transplantation with P value (0.659) (1.000). However, the incidence of CMV infection significantly increased with the increase of trough level of immunosuppressive agent whether tacrolimus or cyclosporin. | ||||
| Keywords | ||||
| Immunosuppressant; Cytomegalovirus infectious disease; Kidney Transplantation | ||||
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