Use of eosin for spectroscopic determination of Adefovir dipivoxil | ||
| Records of Pharmaceutical and Biomedical Sciences | ||
| Volume 8, Issue 1, 2024, Pages 70-79 PDF (898.49 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/rpbs.2024.270833.1270 | ||
| Authors | ||
| Shaimaa Mohamed Elsayed* 1; Alaa Mohamed El-Gendy2; Yasser El-shabrawy3; ElSayed A. Ibrahim4 | ||
| 1Demonstrator at hue University faculty of pharmacy | ||
| 2Professor of Pharmaceutical Analytical Chemistry Faculty of Pharmacy - Suez Canal University | ||
| 3Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. | ||
| 4Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt | ||
| Abstract | ||
| This paper elucidates a new spectrofluorometric method for the determination of Adefovir Dipivoxil in its pharmaceutical dosage form using Eosin, the colored ion - pair complex was produced at λ em 544 nm and excitation at λ ex 267 in acetate buffer solution with a pH of 3.5. The linearity range was 0.1 – 1.5 µg/ml, with a percentage recovery of 99.31, and detection limit of 0.032 µg/ml. The quantification limit was 0.097 µg/ml. The method was successfully applied to determine Adefovir Dipivoxil in its pharmaceutical dosage form. The method was Sensitive, rapid and cost-effective, demonstrating ease of application suitable for routine quality control analysis. | ||
| Keywords | ||
| Eosin; Spectroscopic Determination; Adefovir Dipivoxil | ||
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