Anti- efficacy of and in a neonatal mouse model | ||||
| Kasr Al Ainy Medical Journal | ||||
| Volume 23, Issue 1, January 2017 PDF (831.33 K) | ||||
| DOI: 10.4103/1687-4625.207190 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Mona M. Khater; Shaimaa H. El-Sayed; Hebat-Allah S. Yousof; Soheir S. Mahmoud; Nadia El-Dib; Ayman A. El-Badry | ||||
| Abstract | ||||
| Background Cryptosporidiosis is caused by an opportunistic protozoan parasite . It may be life-threatening in immunocompromised individuals, children and the elderly. To date, no specific therapy has been proven to be effective against , which necessitates exploring for new therapeutics. This study evaluated the anti- therapeutic potential of two natural medicinal plants − (olive leaf extract) and (kiwi fruit pulp extract) − in four different groups of experimentally infected neonatal mice. Materials and methods Anti- efficacies of tested extracts were evaluated in four groups of age-matched neonatal Swiss albino mice parasitologically by detection of oocysts and copro-DNA, using microscopy and nested PCR assay, as well as histopathological examination of their small intestines. Results and conclusion There was a 100% reduction in oocyst excretion in stool and copro-DNA of -treated infected mice after 2 weeks of drug administration, whereas there was persistence of oocysts in the stool of -treated mice until scarification. Obtained results make a promising natural therapeutic for cryptosporidiosis, a scientific case that calls for further clinical trials to replicate this model in human individuals. | ||||
| Keywords | ||||
| Neonatal mice | ||||
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