Exploring Marine Fungal Crude Extracts for Antidiabetic Potential

Abdelazeem, Samah Mohamm; hassan, mervat hass; shora, hammed sh; awady, mohammed el; elghany, ahmed abd; barka, dina ba

doi:10.21608/bjas.2024.284123.1410

	Exploring Marine Fungal Crude Extracts for Antidiabetic Potential
Benha Journal of Applied Sciences
Article 4, Volume 9, Issue 1, January 2024, Page 23-28 PDF (396.08 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2024.284123.1410
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Authors
Samah Mohamm Abdelazeem ¹; mervat hass hassan²; hammed sh shora³; mohammed el awady⁴; ahmed abd elghany⁴; dina ba barka⁵
¹Microbiology,Alazhar university,Cairo
²Botany and Mirobiology,Faculty of science, Benha University, Egypt
³plant and Mirobiology,Faculty of science, Mansoura University, Egypt
⁴Mirobial Biotechnology, National Rsarh Center. Egypt
⁵Botany and Mirobiology,Faculty of science, Benha University, Benha, Egypt
Abstract
This study focused on the exploration of antidiabetic potential within marine fungal communities collected from diverse locations in Hurghada. Various fungi were isolated from Sponge 1, 2, and Sea Grass, exhibiting distinct morphologies. Notable isolates included s289 (white-gray) from Sponge 2, s313 (black) from Sponge 1, and s213 (black) from Sponge 2. Small-scale fermentation and extraction processes were employed to obtain crude extracts, concentrating bioactive secondary metabolites. Evaluation of antidiabetic activity through α-glucosidase inhibition revealed distinct inhibitory potency levels among the extracts. Notably, s313 displayed potent activity (IC50: 0.505 mg/ml), suggesting promising antidiabetic potential. Moderately inhibitory activities were observed for s289 (IC50: 0.972 mg/ml) and s213 (IC50: 0.617 mg/ml). The comparison with the reference drug Acarbose (IC50: 0.375 mg/ml) highlighted the competitive nature of the fungal extracts. This study underscores the diverse bioactivity of marine fungal crude extracts and emphasizes their potential as alternative or complementary antidiabetic agents, encouraging further exploration of natural sources for effective treatments.
Keywords
Relevant Terms; antidiabetic agent; marine fungi; secondary metabolites


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