Value of F-18 FDG PET/CT Compared to Conventional Imaging in changing management of Patients with Differentiated Thyroid Cancer before radioactive iodine ablation.
Elantably, I., Ibrahim, D., Abd El-Gaid, S., abdelhamed, H. (2022). Value of F-18 FDG PET/CT Compared to Conventional Imaging in changing management of Patients with Differentiated Thyroid Cancer before radioactive iodine ablation.. EKB Journal Management System, 25(2), 63-77. doi: 10.21608/egyjnm.2022.173698.1070
Ismail Mohamed Elantably; Dalia Ibrahim; Salwa Abd El-Gaid; Heba Mounir abdelhamed. "Value of F-18 FDG PET/CT Compared to Conventional Imaging in changing management of Patients with Differentiated Thyroid Cancer before radioactive iodine ablation.". EKB Journal Management System, 25, 2, 2022, 63-77. doi: 10.21608/egyjnm.2022.173698.1070
Elantably, I., Ibrahim, D., Abd El-Gaid, S., abdelhamed, H. (2022). 'Value of F-18 FDG PET/CT Compared to Conventional Imaging in changing management of Patients with Differentiated Thyroid Cancer before radioactive iodine ablation.', EKB Journal Management System, 25(2), pp. 63-77. doi: 10.21608/egyjnm.2022.173698.1070
Elantably, I., Ibrahim, D., Abd El-Gaid, S., abdelhamed, H. Value of F-18 FDG PET/CT Compared to Conventional Imaging in changing management of Patients with Differentiated Thyroid Cancer before radioactive iodine ablation.. EKB Journal Management System, 2022; 25(2): 63-77. doi: 10.21608/egyjnm.2022.173698.1070

Value of F-18 FDG PET/CT Compared to Conventional Imaging in changing management of Patients with Differentiated Thyroid Cancer before radioactive iodine ablation.

Egyptian Journal Nuclear Medicine
Volume 25, Issue 2, December 2022, Pages 63-77    PDF (616.98 K)
Document Type: Original Paper, PET/CT
DOI: 10.21608/egyjnm.2022.173698.1070
Authors
Ismail Mohamed Elantably* 1; Dalia Ibrahim2; Salwa Abd El-Gaid3; Heba Mounir abdelhamed4
1Nuclear medicine unit, National cancer institute, Cairo University
2radiodiagnosis department, kasr El-ainy hospital, Cairo University
3Nuclear Medicine Unit, National Cancer Institute (NCI) Cairo University, Cairo, Egypt.
4clinical oncology and nuclear medicine department
Abstract
Aim: to evaluate the value of F-18 FDG PET/CT compared to conventional imaging in change the management of patients with differentiated thyroid cancer before radioactive iodine ablation. Material &Methods: This retrospective study was conducted on hundred twenty-four patients (92 females and 32 males), with pathologically proven DTC. Baseline whole body F-18 FDG PET/CT was done before RAI-131 therapy, then correlated with neck U/S and CT chest findings. Results: The study group was including 92 female and 32 male patients. The F-18 FDG PET/CT was positive in 65 sites in 38 patients (thyroid bed in 22, 15 in cervical LN) and distant sites in 28 patients. Neck U/S and F-18 FDG PET/CT loco-regional assessment showed fair agreement with a statistical significance (P value of <0.001) in detecting regional nodal lesions but no significance difference in operative bed lesions. The degree of agreement of F-18 FDG PET/CT with CT chest results was also conducted using the Kappa test and it showed fair to moderate degree of agreement, F-18 FDG PET/CT results changed the management of 29 patients accounting for 23.4% of the patients.
Conclusion: The initial F-18FDG PET/CT before RAI-131 ablation may change the management in some patients as compared to other imaging modalities in differentiated thyroid cancer and in planning for proper dose of radioiodine therapy.
Keywords
PET/CT; conventional imaging; DTC
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