Evaluating Platelet-Rich Plasma (PRP) for Treatment of Osteoarthritis in Rabbits Involved Histomorphology, Radiology and Biochemical Assessments | ||||
| Egyptian Journal of Veterinary Sciences | ||||
| Volume 56, Issue 6, June 2025, Page 1327-1335 PDF (1.43 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejvs.2024.276578.1909 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ibrahim Fawzy1; Farouk Abdelmohdy1; Ayman S. Atiba2; Foad Farrag3; Mustafa Shukry   4; Mohammed Kassab1
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| 1Department of cytology and histology | ||||
| 2Department of Surgery, Anesthesiology and Radiology | ||||
| 3Department of Anatomy, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt | ||||
| 4Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt | ||||
| Abstract | ||||
| Osteoarthritis (OA), the prevalent type of arthritis, arises from mechanical wear and inflammatory processes. Platelet-rich plasma (PRP), a derivative of blood enriched with activated platelets, offers a rich mixture of growth factors essential for the repair of cartilage. Twelve rabbits were classified into control negative, OA and treated groups. Induction of arthritis was done by Monoiodoacetate (MIA). Treatment is done with PRP. X-ray, histological study, immunohistochemical investigation, and biochemical measuring were done to investigate arthritis of femorotibial joints and its treatment with PRP. MIA-induced OA is characterized by affection on cartilage with fragmentation, apoptosis of chondrocytes, and loss of matrix. Synovitis is characterized by hyperplasia of lining cells, congestion, extravasation and leucocytic infiltration with increased ESR, CRP and IL-6. The PRP-treated group appeared to preserve the typical structure of both cartilage and synovium. in conclusion We confirm the impact of PRP in the treatment of OA by several scores, Mankin and Krestinsin scores. These scores indicate that PRP may be an efficient method for OA treatment. | ||||
| Keywords | ||||
| Osteoarthritis; PRP; Radiology; Histology; Immunohistochemistry | ||||
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