Association between Spot urine Phytoestrogens as Biomarkers on Their Dietary Intake on the Risk of Death from Cancer and Cardiovascular Disease | ||||
Bulletin of the National Nutrition Institute of the Arab Republic of Egypt | ||||
Article 4, Volume 49, Issue 1, November 2017, Page 1-35 PDF (867.48 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bnni.2017.4244 | ||||
View on SCiNiTO | ||||
Authors | ||||
Gamil Mahmud1; Jones Zhang1; Kathryn Josette2; Jones Else3; Shahat S.4 | ||||
1Functional Foods Department, National Institute of Nutrition Canada, Ottawa | ||||
2Center for Disease Prevention and Control, Ontario | ||||
3National Health and Nutrition Examination Survey (NHANES) Canada | ||||
4Food Science and Technology Department, faculty of Agriculture, Al Azhar university, Cairo, Egypt | ||||
Abstract | ||||
This study suggests that phytoestrogen intake alters cancer and cardiovascular risk. This study investigated the associations of urinary phytoestrogens with total cancer (n = 198), cardiovascular (n = 152), and all-cause (n = 363) mortality among 5179 participants in the continuous National Health and Nutrition Examination Survey Canada (2009–2014). Methods Urinary phytoestrogens were measured using high-performance liquid chromatography with tandem mass spectrometric detection. Survival analysis was per-formed to evaluate hazard ratios (HRs) and 95 % confi-dence intervals (CIs) for each of the three outcomes in relation to urinary phytoestrogens. Results: After adjustment for confounders, higher urinary concentrations of total enterolignans were associated with a reduced risk of death from cardiovascular disease (HR for tertile 3 vs. tertile 10.48; 95 % CI 0.24, 0.97), whereas higher urinary concentrations of total isoflavones (HR for tertile 3 vs. tertile 12.14; 95 % CI 1.03, 4.47) and daidzein (HR for tertile 3 vs. tertile 12.05; 95 % CI 1.02, 4.11) were associated with an increased risk death from Cardiovascular Disease. A reduction in all-cause mortality was observed for elevated urinary concentrations of total enterolignans (HR for tertile 3 vs. tertile 10.65; 95 % CI 0.43, 0.96) and enterolactone (HR for tertile 3 vs. tertile 1 0.65; 95 % CI 0.44, 0.97). Conclusions: Some urinary phytoestrogens were associ-ated with cardiovascular and all-cause mortality in a rep-resentative sample of the Canadian population. This is one of the first studies that used urinary phytoestrogens as biomarkers of their dietary intake to evaluate the effect of these bioac-tive compounds on the risk of death from cancer and car-diovascular disease. | ||||
Keywords | ||||
Cancer · Cardiovascular disease · Cohort study · Mortality · Urinary phytoestrogens | ||||
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