Evaluation of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep
A. Y. Helal, M., Hefnawy, A., Y. Abokora, S., S. Koptan, A. (2018). Evaluation of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep. EKB Journal Management System, 35(2), 31-43. doi: 10.21608/bvmj.2018.48553
Mahmoud A. Y. Helal; Abdel-Ghany Hefnawy; Seham Y. Abokora; Ahmed S. Koptan. "Evaluation of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep". EKB Journal Management System, 35, 2, 2018, 31-43. doi: 10.21608/bvmj.2018.48553
A. Y. Helal, M., Hefnawy, A., Y. Abokora, S., S. Koptan, A. (2018). 'Evaluation of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep', EKB Journal Management System, 35(2), pp. 31-43. doi: 10.21608/bvmj.2018.48553
A. Y. Helal, M., Hefnawy, A., Y. Abokora, S., S. Koptan, A. Evaluation of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep. EKB Journal Management System, 2018; 35(2): 31-43. doi: 10.21608/bvmj.2018.48553

Evaluation of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep

Benha Veterinary Medical Journal
Article 3, Volume 35, Issue 2, December 2018, Page 31-43  XML PDF (631.72 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2018.48553
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Authors
Mahmoud A. Y. Helal1; Abdel-Ghany Hefnawy1; Seham Y. Abokora2; Ahmed S. Koptan1
1Department of animal medicine, faculty of veterinary medicine, Benha university –Egypt
2Department of pharmacology, faculty of veterinary medicine, Benha university, Egypt
Abstract
The aim of this study was to evaluate the role of L-carnitine in the treatment of experimentally induced hypomagnesemia in sheep. This study was carried out on 10 ossimi rams aged 10-12 months old with an average live weight of 35±1.1 kg that were used for experimental induction of hypomagnesemia. Rams with induced hypomagnesaemia were divided into two groups according to the line of treatment.  The first group (n=5) was treated by the traditional treatment alone while the second group (n=5) was treated by the traditional treatment in addition to L-carnitine (20 mg/kg I/V). The symptoms of hypomagnesemia appeared gradually until complete appearance of symptoms at day 28 post induction. There was significant decrease (P < 0.05) in serum magnesium (Mg), calcium (Ca), glucose and parathyroid hormone (PTH) in experimentally induced hypomagnesemic rams. However, there were significant increase (P < 0.05) in serum sodium (Na), potassium (K), urea, creatinine, cortisol, creatine phosphokinase (CPK) and troponin I (cTnI) in experimentally induced hypomagnesemic rams. Treatment of hypomagnesemia with traditional treatment and L-carnitine resulted in significant elevation (P < 0.05) of serum Mg, Ca, glucose and PTH in hypomagnesemic rams than traditional treatment only. However, there were significant reduction (P < 0.05) in serum K, urea, CPK and cTnI than traditional treatment only at 24 hour after treatment. Based on the results of this study we concluded that the addition of L-carnitine to the traditional treatment of hypomagnesaemia in sheep is effective and produced earlier and more pronounced recovery.
Keywords
experimental; hypomagnesemia; L-carnitine; sheep; Treatment
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