Hepatoprotective Effects of Crude Phenolic-rich Extract from Oyster Mushroom (Pleurotus ostreatus) | ||||
| Egyptian Journal of Food Science | ||||
| Article 13, Volume 47, Issue 2, 2019, Page 157-164 PDF (1.13 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejfs.2019.16213.1017 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ali Osman1; Abbas Omar Toliba  2
| ||||
| 1Biochemistry Department, Faculty of Agriculture, Zagazig University, 44511, Zagazig, Egypt | ||||
| 2Food sci. Dept., Fac. Agric., Zagazig Univ., Zagazig., Egypt. | ||||
| Abstract | ||||
| In this study the hepatoprotective activity of the crude phenolic rich extract (CPRE) isolated from oyster mushrooms on carbon tetrachloride (CCl4)-induced oxidative stress was investigated in albino rats. The hepatoprotective activity was examined through various biochemical parameters. Administration of CCl4 for 28 days exhibited a significant increase (P<0.05) in serum markers of liver damage, i.e., alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, urea, creatinine, total lipids and triglycerides. Whereas, the serum markers were significantly decreased (P<0.05) by CPRE administration. CCl4 exposure significantly decreased (P<0.05) the hepatic antioxidant enzyme activities such as superoxide dismutase and glutathione peroxidase. Contrarily, the CPRE treatments showed significant increases (P<0.05) in these hepatic activities. The results obtained from this study clearly validated the potential antioxidant activity of CPRE isolated from oyster mushrooms against several oxidation systems in-vivo, which contributed to its hepatoprotective effects in CCl4-induced liver injury in male albino rats. Finally, oyster mushrooms could be added as an additional nutrient to food products as it constitutes a new potential source of natural antioxidant and antibacterial agents. | ||||
| Keywords | ||||
| Oyster mushrooms; Pleurotus ostreatus; Phenolic compounds; CCl4; Hepatoprotective; Oxidative Stress | ||||
|
Statistics Article View: 348 PDF Download: 399 |
||||
