Modulation of Nephrotoxicity Induced by Gentamicin with Bone Marrow Mesenchymal Stem Cells and Moringa Oleifera Extract
Ismaiel, E., Abd El-Latif, H., Mohammed, H., Abd El Fattah, M., Rashed, L., Abdel-Wahhab, N. (2019). Modulation of Nephrotoxicity Induced by Gentamicin with Bone Marrow Mesenchymal Stem Cells and Moringa Oleifera Extract. EKB Journal Management System, 62(Special Issue (Part 2) Innovation in Chemistry), 751-763. doi: 10.21608/ejchem.2019.18347.2129
Elsaid AM Ismaiel; Hekma A Abd El-Latif; Hagar E Mohammed; May A Abd El Fattah; Laila Rashed; Nossad Attia Abdel-Wahhab. "Modulation of Nephrotoxicity Induced by Gentamicin with Bone Marrow Mesenchymal Stem Cells and Moringa Oleifera Extract". EKB Journal Management System, 62, Special Issue (Part 2) Innovation in Chemistry, 2019, 751-763. doi: 10.21608/ejchem.2019.18347.2129
Ismaiel, E., Abd El-Latif, H., Mohammed, H., Abd El Fattah, M., Rashed, L., Abdel-Wahhab, N. (2019). 'Modulation of Nephrotoxicity Induced by Gentamicin with Bone Marrow Mesenchymal Stem Cells and Moringa Oleifera Extract', EKB Journal Management System, 62(Special Issue (Part 2) Innovation in Chemistry), pp. 751-763. doi: 10.21608/ejchem.2019.18347.2129
Ismaiel, E., Abd El-Latif, H., Mohammed, H., Abd El Fattah, M., Rashed, L., Abdel-Wahhab, N. Modulation of Nephrotoxicity Induced by Gentamicin with Bone Marrow Mesenchymal Stem Cells and Moringa Oleifera Extract. EKB Journal Management System, 2019; 62(Special Issue (Part 2) Innovation in Chemistry): 751-763. doi: 10.21608/ejchem.2019.18347.2129

Modulation of Nephrotoxicity Induced by Gentamicin with Bone Marrow Mesenchymal Stem Cells and Moringa Oleifera Extract

Egyptian Journal of Chemistry
Article 23, Volume 62, Special Issue (Part 2) Innovation in Chemistry, December 2019, Page 751-763  XML PDF (974.22 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2019.18347.2129
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Authors
Elsaid AM Ismaiel1; Hekma A Abd El-Latif1; Hagar E Mohammed2; May A Abd El Fattah1; Laila Rashed3; Nossad Attia Abdel-Wahhab email orcid 4
1Department of Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University, Cairo
2Department of Zoology, Faculty of Science, Arish University, Arish, Egypt
3Department of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt
4Department of Food Toxicology & Contaminants. National Research Center
Abstract
The study was undertaken to evaluate the protective effect of bone marrow mesenchymal stem cells (BM-MSCs) and Moringa oleifera extract (MOE) against gentamicin (GN)-induced nephrotoxicity in male albino rats. Thirty two adult male rats were divided into four groups including the control group, the group injected i.p with a single dose of GN (100 mg/kg b.w), the group treated orally with MOE (400 mg/kg b.w) for 6 days then injected with a single dose of GN and the group was injected with a single dose of BM-MSCs (5x105cells) by tail vein then injected with GN. At the end of experiment blood and kidney tissue samples were collected for estimation of different biochemical parameters. The results recorded a significant increase in BUN, serum KIM-1, cystatin C, creatinine, sodium and renal MDA accompanied with a significant decrease in serum calcium, renal GSH, SOD and CAT in GN alone-treated group as compared to control group. Co administration of MOE or BM-MSCs before GN injection improved all above parameters when compared with GN administered group. It could be concluded that MOE and BM-MSCs have a therapeutic and protective action against AKI induced by GN administration which manifested by lowering kidney markers and MDA contents and elevation in antioxidant profile.
Keywords
Gentamycin; Nephrotoxicity; Bone marrow mesenchymal stem cells; Moringa oleifera
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