SYNTHESIS OF SOME NOVEL 1, 3, 5-TRISUBSTITUTED [1,2,4]TRIAZOLE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 15, Volume 31, Issue 2, December 2008, Page 375-390 PDF (240.51 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.2008.64342 | ||||
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Authors | ||||
Alaa M. Hayallah* 1; Helal F. Heta2 | ||||
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt | ||||
2Department of Microbiology and immunology, Faculty of Medicine, Assiut University, Assiut 71526, Egypt | ||||
Abstract | ||||
In the present work, some new 1,3,5-trisubstituted[1,2,4]triazole derivatives and their Schiff's bases were synthesized. The chemical structure of the target compounds was confirmed by IR, 1H-NMR, 13C-NMR, FAB-MS, EI-HRMS spectra and elemental analyses. The title compounds were tested for their in vitro antibacterial activity against Gram-positive and Gram-negative ones using ampicillin and nalidixic acid as reference drugs. Some of them showed antibacterial activity more significant than the reference drugs. | ||||
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