ANTIOXIDANT, LIPID PEROXIDATION-INHIBITORY AND ANTIULCER ACTIVITIES OF BROWN PROPOLIS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 6, Volume 33, Issue 2, 2010, Page 169-177 PDF (484.27 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2010.64741 | ||||
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| Authors | ||||
| Omar Mahmoud Mohamed Mohafez1; Ihab Talat Abdel-Raheem2; Alaa Mohamed Nafady* 3 | ||||
| 1Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt. | ||||
| 2Department of Pharmacology and oxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt | ||||
| 3Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524,Egypt | ||||
| Abstract | ||||
| The antioxidant activity of the ethanolic extract of brown propolis was determined by invitro antioxidant assays via 1,1-diphenyl-2-picryl-hydrazyl (DPPH·) free radical scavenging activity and phosphomolybdenum method. The brown propolis extract had an effective DPPH· scavenging activity at 20-200ìg/ml concentrations. Moreover, the in-vivo experiments showed that brown propolis extract has a powerful antioxidant and lipid peroxidation inhibitory activity in the liver tissues challenged with CCl4. On the other hand, we found that pretreatment of rats with propolis extract protected gastric tissues against indomethacin-induced gastropathy as demonstrated from reduction in the ulcer index, attenuation of histopathological changes and amelioration of the altered oxidative stress biomarkers like glutathione, thiobarbituric acid reactive substance levels and superoxide dismutase act ivi ty in gastric tissues. In conclusion, total ethanolic extract of brown propolis exposed major anti-oxidant and anti-ulcer activities. | ||||
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