Synergistic curative effect of Boswellic acid and Cisplatin against Diethyl nitrosamine -induced hepatocellular carcinoma
Elgendy, A., Abo zaid, O., And elhamid, O., Mansour, S. (2019). Synergistic curative effect of Boswellic acid and Cisplatin against Diethyl nitrosamine -induced hepatocellular carcinoma. EKB Journal Management System, 36(2), 256-263. doi: 10.21608/bvmj.2019.14254.1042
Abeer Ebrahim Elgendy; omayma ragab Abo zaid; Omnia Mahmoud And elhamid; somaya Zakria Mansour. "Synergistic curative effect of Boswellic acid and Cisplatin against Diethyl nitrosamine -induced hepatocellular carcinoma". EKB Journal Management System, 36, 2, 2019, 256-263. doi: 10.21608/bvmj.2019.14254.1042
Elgendy, A., Abo zaid, O., And elhamid, O., Mansour, S. (2019). 'Synergistic curative effect of Boswellic acid and Cisplatin against Diethyl nitrosamine -induced hepatocellular carcinoma', EKB Journal Management System, 36(2), pp. 256-263. doi: 10.21608/bvmj.2019.14254.1042
Elgendy, A., Abo zaid, O., And elhamid, O., Mansour, S. Synergistic curative effect of Boswellic acid and Cisplatin against Diethyl nitrosamine -induced hepatocellular carcinoma. EKB Journal Management System, 2019; 36(2): 256-263. doi: 10.21608/bvmj.2019.14254.1042

Synergistic curative effect of Boswellic acid and Cisplatin against Diethyl nitrosamine -induced hepatocellular carcinoma

Benha Veterinary Medical Journal
Article 26, Volume 36, Issue 2, June 2019, Page 256-263  XML PDF (1.35 MB)
Document Type: Original Article
DOI: 10.21608/bvmj.2019.14254.1042
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Authors
Abeer Ebrahim Elgendy email 1; omayma ragab Abo zaid2; Omnia Mahmoud And elhamid2; somaya Zakria Mansour3
1Biochemistry department faculty of science tanta university
2Biochemistry veterinary medicine Banha university
3Radiation Biology Department, National Centre for Radiation Research and Technology. Egypt.
Abstract
Hepatocellular carcinoma (HCC) is a primary malignancy of hepatocyte. Boswellic acids are the effective components of gum resin of Boswellia serrata, which have anti-inflammatory properties. Cisplatin is used as a chemotherapeutic agent for treatment of HCC. The present study aims to evaluate the role of Boswellic acid in HCC treatment and as a chemo-sensitizer for Cisplatin treatment of HCC in rats that is induced by orally administration of Diethyl nitrosamine (DEN). Sixty rats were divided in to sex groups, 10 rats each, group 1: normal control group, group 2: cisplatin (1.5 mg/Kg b.wt), group 3: received the Diethyl nitrosamine (DEN) (20 mg/kg b.wt), group 4: received DEN as in group 3 and then treated with cisplatin, group 5: received DEN as in group 3 and then treated with Boswellic acid (500 mg/kg b.wt) and group 6: received DEN as in group 3 and then treated with cisplatin and Boswellic acid. After 10 weeks animals were sacrificed and liver tissue were removed for Histopathological and tissue parameters examination. A significant increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) activity, a significant decrease in serum albumin concentration. Also a significant increases in liver transforming growth factor-beta 1 (TGF-b1), B-cell lymphoma 2 (Bcl-2) and nuclear factor kappa β (NF-kβ) concentrations and a significant decrease in Caspase.3 activity were recorded in DEN-treated rats while treatment with Boswellic acid and Cisplatin reduced the severity of HCC and enhanced histopathological findings, these result suggesting the efficacy of Boswellic acid supplementation as an anti-HCC.
Keywords
HCC; Boswellic acid; Bcl2; NF-kβ and Caspase.3
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