Evaluation of pilocarpine potentiality to counteract the rat parotid gland structural alterations induced by gamma irradiation | ||||
| Al-Azhar Journal of Dental Science | ||||
| Article 4, Volume 21, Issue 3, July 2018, Page 221-227 PDF (2.19 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajdsm.2018.71527 | ||||
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| Authors | ||||
| Said M. Hani* 1; Abd Elnasser A. Elmawla* 2; Ashraf M. Emran* 3; Salwa F. Ahmed4 | ||||
| 1Professor of Oral Histology and Pathology, Oral biology department, faculty of dental medicine, Azhar University. | ||||
| 2Assistant Professor of Oral histology, Oral biology department, faculty of dental medicine, Al-Azhar University. | ||||
| 3Demonstrator of oral histology, Oral Biology Department, faculty of dental medicine, Al-Azhar University | ||||
| 4Lecture in Health Radiation Research Department, National Center for Radiation Research and Technology | ||||
| Abstract | ||||
| The effect of pilocarpine on irradiation induced rat parotid gland structural alterations was evaluated in 45 adult male Sprague- Dawley rats used in this study and they were divided into three groups,15 rats each. The control group rats did not expose to pilocarpine not radiation. The experimental group II rats were irradiated while those of group III were primarily treated by pilocarpine before irradiation. At 1,4 and 16 weeks after irradiation exposure, 5 rats from each group were euthanasially decapitated. Then the parotid glands were carefully dissected out and prepared for stain by hematoxylin and eosin stain. The histological examination showed that radiation induced harmful effects on the parotid gland were significantly reduced with pilocarpine. Conclusion: Pilocarpine, the parasympathomimetic agonist known to stimulate the various exocrine glands, has considerable improvement for the injurious radiation effects on salivary glands. | ||||
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