Evaluation of the effect of Garlic on the expression of NF-κB in DMBA-induced oral carcinogenesis in albino rats: An Animal study
Zayed, S., Ali, S. (2017). Evaluation of the effect of Garlic on the expression of NF-κB in DMBA-induced oral carcinogenesis in albino rats: An Animal study. EKB Journal Management System, 63(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 2321-2328. doi: 10.21608/edj.2017.76048
Shaimaa Omar Zayed; Shereen Ali. "Evaluation of the effect of Garlic on the expression of NF-κB in DMBA-induced oral carcinogenesis in albino rats: An Animal study". EKB Journal Management System, 63, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2017, 2321-2328. doi: 10.21608/edj.2017.76048
Zayed, S., Ali, S. (2017). 'Evaluation of the effect of Garlic on the expression of NF-κB in DMBA-induced oral carcinogenesis in albino rats: An Animal study', EKB Journal Management System, 63(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 2321-2328. doi: 10.21608/edj.2017.76048
Zayed, S., Ali, S. Evaluation of the effect of Garlic on the expression of NF-κB in DMBA-induced oral carcinogenesis in albino rats: An Animal study. EKB Journal Management System, 2017; 63(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 2321-2328. doi: 10.21608/edj.2017.76048

Evaluation of the effect of Garlic on the expression of NF-κB in DMBA-induced oral carcinogenesis in albino rats: An Animal study

Egyptian Dental Journal
Article 5, Volume 63, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), July 2017, Page 2321-2328  XML PDF (2.22 MB)
Document Type: Original Article
DOI: 10.21608/edj.2017.76048
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Authors
Shaimaa Omar Zayed1; Shereen Ali2
1Lecturer, Department of Oral Pathology, Faculty of dentistry, Cairo University.
2Lecturer, Department of Oral Medicine and Periodontology, Faculty of dentistry, Cairo University. Lecturer, Department of Oral Medicine, Periodontology and Oral Radiology, Faculty of dentistry, Misr International University (MIU).
Abstract
Background: Nuclear factor-kappa B (NF-κB) is a key player in the process of carcinogenesis via regulating various steps, thus it is an attractive target for cancer therapy. Many medicinal plants and nutraceuticals can modulate NF-κB signaling pathway. The aim of this study is to investigate the chemopreventive and immunomodulatory effect of garlic in 7, 12 Dimethylbenz [a] anthracene (DMBA) induced oral carcinogenesis by assessing the expression of NF-κB.
Material and methods: DMBA was used to induce oral cancer in 75 male albino rats. The animals were randomized into five groups (1 control and 4 experimental groups). The control group received no DMBA nor garlic extract, the other groups received either DMBA, garlic extract alone or both of them.
Results: NF-κB immunoexpression revealed the highest values in group (2) and group (5) showing a highly significant difference.
Conclusion: The aqueous garlic extract could prevent oral cancer through inhibition of
NF-κB activation, where its effect is more pronounced in the initiation phase than the promotion and progression phases.
Keywords
oral carcinogenesis; Garlic; Nuclear Factor-kappa B
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