Anti-Helicobacter Pylori, Anti-diabetic and Cytotoxicity Activity of Biosynthesized Gold Nanoparticles Using Moricandia nitens Water Extract
Khalil, M., Soliman, N., Abdel- Moaty, H., Ismael, E., Sabry, D. (2018). Anti-Helicobacter Pylori, Anti-diabetic and Cytotoxicity Activity of Biosynthesized Gold Nanoparticles Using Moricandia nitens Water Extract. EKB Journal Management System, 61(4), 691-703. doi: 10.21608/ejchem.2018.3744.1318
Mostafa M.H. Khalil; Nadia Soliman; Heba I Abdel- Moaty; Eman Ismael; Dina Y. Sabry. "Anti-Helicobacter Pylori, Anti-diabetic and Cytotoxicity Activity of Biosynthesized Gold Nanoparticles Using Moricandia nitens Water Extract". EKB Journal Management System, 61, 4, 2018, 691-703. doi: 10.21608/ejchem.2018.3744.1318
Khalil, M., Soliman, N., Abdel- Moaty, H., Ismael, E., Sabry, D. (2018). 'Anti-Helicobacter Pylori, Anti-diabetic and Cytotoxicity Activity of Biosynthesized Gold Nanoparticles Using Moricandia nitens Water Extract', EKB Journal Management System, 61(4), pp. 691-703. doi: 10.21608/ejchem.2018.3744.1318
Khalil, M., Soliman, N., Abdel- Moaty, H., Ismael, E., Sabry, D. Anti-Helicobacter Pylori, Anti-diabetic and Cytotoxicity Activity of Biosynthesized Gold Nanoparticles Using Moricandia nitens Water Extract. EKB Journal Management System, 2018; 61(4): 691-703. doi: 10.21608/ejchem.2018.3744.1318

Anti-Helicobacter Pylori, Anti-diabetic and Cytotoxicity Activity of Biosynthesized Gold Nanoparticles Using Moricandia nitens Water Extract

Egyptian Journal of Chemistry
Article 12, Volume 61, Issue 4, July and August 2018, Page 691-703  XML PDF (2.89 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2018.3744.1318
View on SCiNiTO View on SCiNiTO
Authors
Mostafa M.H. Khalil email orcid 1; Nadia Soliman2; Heba I Abdel- Moaty3; Eman Ismael4; Dina Y. Sabry5
1Chemistry Department, Faculty of Science, Ain Shams University
2Faculty of Science ,Chemistry Department,Ain Shams University,Cairo
3Medicinal and Aromatic Plants Department, Desert Research Center, El-Mataria, Cairo, Egypt
4Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt
5Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt
Abstract
This study aims to synthesize gold nanoparticles (AuNPs) using water extract of Moricandia nitens (Viv.) E. A. Durand & Barratte aerial parts water extract. The presence of various phytochemicals viz. alkaloids, carbohydrates, glycosides, flavonoids, tannins, cumarines, protein and saponins by following standard biochemical methods was investigated. The effect of different parameters such as extract concentration, pH and temperature on the size and morphology of the gold nanoparticles (AuNPs) were studied. The synthesized gold nanoparticles (AuNPs) were characterized by using UV-Vis spectroscopy, FTIR and XRD. The synthesized nanoparticles were found to be spherical in shape with average size in the range of 5 to 20 nm. The green synthesized GNPs were found to be potent inhibitors of α-glucosidase with an IC50 value of 159.3 μg/ml and showed anti-Helicobacter pylori activity against multidrug resistant H. pylori strains with an MIC 31.25 (µg/ml). Furthermore, biogenic AuNPS possess more significant anticancer activity against HepG2 and HCT-116 withIC50 =44.6 ± 0.8 µg/ml and IC50 = 36 ± 0.7 µg/ml respectively.
Keywords
Moricandia nitens; Anti-Helicobacter pylori; anti-diabetic; AuNPs; Anticancer activity; HepG2, HCT-116
Statistics
Article View: 782
PDF Download: 709