The Role of HSP70, CD34 and Ki 67 Expression in Liver Cirrhosis and Hepatocellular Carcinoma, Immunohistochemical Study
Abdel Raheem,, S., Saied, A., Mater, E. (2018). The Role of HSP70, CD34 and Ki 67 Expression in Liver Cirrhosis and Hepatocellular Carcinoma, Immunohistochemical Study. EKB Journal Management System, 10(1), 91-101. doi: 10.21608/eajbsd.2018.85875
Sayed Abdel Raheem,; Abdel Naby Saied; Emadeldin R. Mater. "The Role of HSP70, CD34 and Ki 67 Expression in Liver Cirrhosis and Hepatocellular Carcinoma, Immunohistochemical Study". EKB Journal Management System, 10, 1, 2018, 91-101. doi: 10.21608/eajbsd.2018.85875
Abdel Raheem,, S., Saied, A., Mater, E. (2018). 'The Role of HSP70, CD34 and Ki 67 Expression in Liver Cirrhosis and Hepatocellular Carcinoma, Immunohistochemical Study', EKB Journal Management System, 10(1), pp. 91-101. doi: 10.21608/eajbsd.2018.85875
Abdel Raheem,, S., Saied, A., Mater, E. The Role of HSP70, CD34 and Ki 67 Expression in Liver Cirrhosis and Hepatocellular Carcinoma, Immunohistochemical Study. EKB Journal Management System, 2018; 10(1): 91-101. doi: 10.21608/eajbsd.2018.85875

The Role of HSP70, CD34 and Ki 67 Expression in Liver Cirrhosis and Hepatocellular Carcinoma, Immunohistochemical Study

Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry
Article 7, Volume 10, Issue 1, December 2018, Page 91-101  XML PDF (557.65 K)
Document Type: Original Article
DOI: 10.21608/eajbsd.2018.85875
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Authors
Sayed Abdel Raheem,; Abdel Naby Saied; Emadeldin R. Mater
Department of Pathology, Faculty of Medicine, Al Azhar University, Cairo
Abstract
Background: Liver cirrhosis is an important risk factor for hepatocellular carcinoma (HCC).
Aim: To evaluate the expression of HSP70, CD34, and Ki 67 in liver cirrhosis and early HCC.
Methods: 60 liver biopsies were classified into 3 groups;Group 1(Control; 10 biopsies), Group 2 (Liver Cirrhosis; 25 cases), and Group 3 (HCC; 25 cases). All biopsies were stained by (H&E), Heat Shock Protein 70 (HSP70), CD34, and Ki67.
Results: HSP70 was negative in 10 out of 10 control cases (100%), low expressed (+) in 2 out of 25 cirrhotic cases (8%), and positive in 25 out of 25 HCC cases (100%); low expressed (+) in 5 cases (5 out of 5 well-differentiated HCC) (20%);, intermediate expressed (++) in 13 cases(11 out of 11 moderately differentiated HCC and 2 out of 9 poorly differentiated HCC) (52%), and high expressed (+++) in 7 cases (7 out of 9 poorly differentiated HCC) (28%). CD34 was negative in all control cases, while in cirrhotic cases, it is minimally expressed in 5 cases (20%) and diffuse in 6 cases (24%) and positive in all cases of HCC; focal in one case (4%) and diffuse in 24 cases (96%). KI67 was negative in all control cases, isolated positively in one cirrhotic case (4%) while in HCC, it was negative in 2 cases (8%), isolated positive in 9 cases (36%), focal positive in 10 cases (40%) and diffusely positive in 4 cases (16%).
Conclusion; there is a role of HSP70, CD34, and Ki-67 in differentiation between non-neoplastic cirrhotic lesions and early HCC.
Keywords
HSP70; CD34; Ki-67; liver cirrhosis and HCC
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