Moringa Oleifera improve lipid metabolic disorders in obesity induced oxidative stress in rats | ||||
| Benha Veterinary Medical Journal | ||||
| Article 41, Volume 35, Issue 2, December 2018, Page 380-395 PDF (311.83 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bvmj.2018.96443 | ||||
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| Authors | ||||
| Samy A. Hussein; Yakout A. El-Senosi; Ghada, H. EL-Sharkawy | ||||
| Department of Biochemistry, Faculty of Vet. Med., Benha University, Egypt. | ||||
| Abstract | ||||
| Moringa Oleifera leaves have therapeutic functions such as antioxidant, anti-bacterial, anti-viral, anti-cancer, anti-inflammatory, anti-allergic and anti-diabetic. The purpose of this study was to evaluate the protective effect of Moringa Oleifera on obesity induced oxidative stress and biochemical abnormalities in male rats. Forty-eight male albino rats were divided into three equal groups. Group I (control normal): rats fed normal diet. Group II (Obesity): rats received high fat diet (HFD).Group III (Obesity+ Moringa oleifera): rats received Moringa Oleifera (600 mg/kg.b.wt.) orally for two months after induction of obesity. The obtained results showed significant increase in levels of serum insulin, lipids profile (total cholesterol and triacylglycerols), liver L-MDA in addition to up regulation of Leptin and Nuclear factor kappa B (NF-κB) gene expression level in obese rats. However, liver catalase activity and GSH concentration were markedly decreased. Moringa Oleifera treatment to high fat diet-induced obesity in rats caused significant improvement of all previous parameters towards its normal ranges. These results suggested that, Moringa Oleifera treatment exerts a protective effect on obesity by reduction of oxidative stress markers, inflammation and hyperlipidemia in rats through free radical scavenging and anti-inflammatory activities as well as regenerating endogenous antioxidant defense system mechanisms. | ||||
| Keywords | ||||
| Obesity; Moringa Oleifera; oxidative stress; leptin; NF-κB | ||||
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