Potential Toxicity Evaluation for a Nano-modified Veneering Ceramic System. Experimental Study in Dogs | ||||
| Egyptian Dental Journal | ||||
| Article 5, Volume 67, Issue 1 - January (Fixed Prosthodontics, Removable Prosthodontics and Dental Materials), January 2021, Page 531-536 PDF (700.69 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/edj.2020.43959.1275 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Radwa Eldessouky  1; Khaled Ali2
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| 1Assistant Lecturer, Fixed Prosthodontics Dept., School of Dentistry, Tanta University. | ||||
| 2Lecturer of Surgery and Anaesthesiology, Faculty of Veterinary Medicine, Cairo University | ||||
| Abstract | ||||
| Abstract Statement of problem: Although feldspathic porcelain is esthetic and biocompatible, it’s considered a weak point in zirconia restorations. Researches are necessary to improve its flexural strength without affecting biological properties. Purpose: to evaluate the possible toxic effects of incorporating ZrO2 Nanoparticles into conventional veneering ceramic system. Materials & Methods: Four veneering ceramic systems [Ex0, Ex5, Ex10&Ex20] were formulated by incorporating zirconia NPs into feldspathic powder [0%, 5%,10% & 20% wt.] respectively. Twenty dogs were grouped into 4 groups to receive the 4 experimental ceramic systems. The 3rd mandibular premolar for each dog was prepared for zirconia crowns. Impressions were taken for production of zirconia copings, veneered with experimental ceramics & delivered. After 3& 6months gingival specimens were collected& subjected to Real-time PCR test to assess genotoxicity of the 4 experimental veneering ceramics. Results: No genotoxicity was recorded for all groups in both 3& 6 months. However, appoptic genes recorded in Ex0: 0.64±0.01 &0.65±0.02, Ex5: 0.67±0.02& 0.67±0.01, Ex10:0.72±0.01&0.73±0.02 and in Ex20: 0.88±0.01& 0.89±0.01 compared to control (housekeeping gene) 0.96± 0.01 & 0.99±0.01 for3&6 months respectively. From clinical perspective; No local biological reactions were recorded. Conclusion: No genotoxic effect was recorded in all groups. whereas, appoptic genes expressed higher level in proportional to NPs ratio. Generally, a satisfactory soft tissue response was observed. | ||||
| Keywords | ||||
| Toxicity; Nano-modified; Veneering Ceramic | ||||
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