Pathological Aspects of Rabbits Hepatotoxicity and Fibrosis Experimentally Induced by Thioacetamide and The Role of Silymarin as Anti fibrotic Effects | ||||
| Egyptian Journal of Veterinary Sciences | ||||
| Volume 54, Issue 1, January and February 2023, Page 23-30 PDF (1.99 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejvs.2022.155404.1379 | ||||
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| Authors | ||||
Angham G Faisul1; Ahmed Al-Saidya   2
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| 1Department of Pathology and Poultry diseases , College if Veterinary Medicine , University of Mosul , Mosul , Iraq | ||||
| 2Department of Pathology and Poultry Diseases, College of Veterinary Medicine, University of Mosul, Mosul, Iraq | ||||
| Abstract | ||||
| This study was designed to estimate the pathological aspects of hepatotoxicity and fibrosis of the liver using Thioacetamide (TAA) and the hepatoprotective effects of Silymarin in rabbits via biochemical tests and histopathological changes. A total of 24 male rabbits were used, randomly separated into 4 groups: Group I worked as a negative control, group II treatedwith Silymarin only by oral administration, group III was given IP injection TAA only, and finally Group IV was given TAA followed by Silymarin through oral route. Results revealed that rabbits treated with TAA had indicated a significant rise in total serum bilirubin, alkaline phosphatase, aspartate transaminase, and alanine transaminase levels. Histopathologically, liver sections showed severe centrilobular, periportal, hepatocellular vacuolation and necrosis respectively. Cholangitis with severe collagen fibres deposition was detected in the portal area accompanied by biliary duct epithelium hyperplasia and ductal fibrosis. The treatment with Silymarin followed by TAA exposure leads to enhancement of both biological parameters and pathological features of the liver in Group IV. Finally, the present study concludes that Silymarin has a hepatoprotective and anti-fibrotic activity mechanism. | ||||
| Keywords | ||||
| Histopathology; Liver; Fibrosis; TAA; Silymarin | ||||
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